Synthetic polymers responsive to temperature and/or pH changes The most studied synthetic responsive polymer is Polymer produced by a living organism. 2. Polymers are traditionally used in plastics, rubber, and coatings. Other polymers used for biomedical applications due to their biocompatibility, controllable degradation rate and their degradation into non-toxic components, include natural polymers, such as polysaccharides or proteins and synthetic polymers, such as: poly(glycolic acid) (PGA), poly(hydroxyl butyrate) (PHB) and poly (ε-caprolactone) (PCL). Polymers are important and attractive biomaterials for researchers and clinical applications due to the ease of tailoring their chemical, physical and biological properties for target devices. Copyright © 2018 Qiang Wei et al. Article Processing Charges Open Access Policy Institutional Open Access Program Editorial Process Awards Research and … These applications require particular physicochemical, biological, and degradation properties of the materials to deliver effective therapy. Information. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The research articles in this issue extend the application of synthetic polymers in both basic research and therapeutics. natural or artificial polymers with a highly conductive material o ers new options for biomedical applications requiring conductive biocompatible components [34–36]. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Plant-derived resorbable polymers in tissue engineering 3. Title:Biocompatible Polymers and their Potential Biomedical Applications: A Review VOLUME: 25 ISSUE: 34 Author(s):Uzma Arif, Sajjad Haider, Adnan Haider*, Naeem Khan*, Abdulaziz A. Alghyamah, Nargis Jamila, Muhammad Imran Khan, Waheed A. Almasry and Inn-Kyu Kang Affiliation:Department of Chemistry, Kohat University of Science and Technology, Kohat, KPK, Department of Chemical … Biostability and biodegradability are the two important parameters to be noticed to select a … lends itself to biomedical applications and in this review the aim is to highlight selected yet diverse recent research showing the potential for bringing these classes of materials into therapeutic use. This is attested by their widespread use in various medical applications. One review article “Strain and Vibration in Mesenchymal Stem Cells” focuses on the effect of various culture conditions and strain or vibration parameters to review the response of mesenchymal stem cells to vibration and cyclic tension and then discuss how polymer scaffolds influence cell response to vibration and strain. Therefore, we launch this special issue, including two review articles and four research articles, to summarize the application of synthetic polymers in biomedical engineering and to illustrate the new development of polymeric biomaterials. The book provides an up-to-date overview of the diverse medical applications of advanced polymers. Classification Biomedical Polymers Natural Polymers Synthetic Polymers 6 7. Applications of synthetic polymers in clinical medicine. Abstract. Biomedical Applications of Synthetic and Natural Biodegradable Polymers Manpreet Kaur Department of Biotechnology, Himachal Pradesh University, Summerhill, Shimla, India Title:Biomedical Applications of Synthetic, Biodegradable Polymers for the Development of Anti-Infective Strategies VOLUME: 21 ISSUE: 29 Author(s):Serban Bertesteanu, Mariana Carmen Chifiriuc, Alexandru Mihai Grumezescu, Atnanasia G. Printza, Thill Marie-Paule, Valentina Grumezescu, Vlad Mihaela, Veronica Lazar and Raluca Grigore However, their application is limited because of their insolubility or pH-dependent solubility and lack of functional groups . Multiple biological, synthetic and hybrid polymers are used for multiple medical applications. A wide range of different polymers are available, and they have the advantage to be tunable in physical, chemical and biological properties and in a wide range to match the requirements of specific applications. Synthetic Polymers for Biomedical Applications, Max Planck Institute for Medical Research, Heidelberg, Germany, University of Freiburg, Freiburg, Germany. Review articles are excluded from this waiver policy. These two review articles indicate the importance of synthetic polymer scaffold in basic research and therapeutics, respectively. This review discusses recent advanced engineering methods to fabricate hydrogels for biomedical applications with emphasis in cardiac constructs and wound healing. These are used to gauge, treat, boost, or substitute any tissue, organ or function of the body. Synthetic polymers can be designed and synthesized with a broad variety of structures and appropriate physical and chemical properties for suitable applications. We appreciate the great effort and the kind contributions from the authors and reviewers to this special issue. This section summarizes recent developments in the functional modifications of poly(amino acids) focusing on the … Copyright © 2020 Elsevier B.V. or its licensors or contributors. ... 39 Biomedical polymers are essentially a biomaterial, that is used and adapted for a medical application. In the article “Influence of Processing Conditions on the Mechanical Behavior and Morphology of Injection Molded Poly(lactic-co-glycolic acid) 85:15,” an overview is provided among processing conditions, morphology, and mechanical property relationship of injection molded PLGA. Many opportunities exist for the application of synthetic biodegradable polymers in the biomedical area particularly in the fields of tissue engineering and controlled drug delivery. Biomaterials can be broadly classified into: metals, ceramics, natural or synthetic polymers and composites(1). Synthetic poly(lactic-co-glycolic acid) (PLGA) is widely considered as a base material for biomedical applications due to its good biocompatibility and degradability. We use cookies to help provide and enhance our service and tailor content and ads. Synthetic polymers can be designed and synthesized with a broad variety of structures and appropriate physical and chemical properties, which are of increasing interest in a wide range of biomedical applications as diverse as tissue engineering, drug delivery, therapeutics, diagnostics, and so on. Purchase Advanced Functional Polymers for Biomedical Applications - 1st Edition. In practice, however, pure insoluble poly (amino acids) have found little utility because of their high crystallinity, which makes them difficult to process and results in relatively slow degradation. As a result, a wide range of natural or synthetic polymers able to undergo hydrolytic or enzymatic degradation is being studied for biomedical applications. Multiple biological, synthetic and hybrid polymers are used for multiple medical applications. Polymers represent the largest and most promising class of biomaterials. Production and hosting by Elsevier B.V. https://doi.org/10.1016/j.bsbt.2015.08.002. Peer review under responsibility of Southwest Jiaotong University. Epub 2015 Apr 30. For all intents and purposes, conductive polymers can be described as Nobel Prize-winning materials, given that their discoverers were awarded the Nobel Prize in Chemistry in 2000. Journals. Highlighting dynamic developments in polymer synthesis, this book focuses on the chemical techniques to synthesize and characterize biomedically relevant polymers and macromolecules. In the article “Efficient Self-Assembly of mPEG End-Capped Porous Silica as a Redox-Sensitive Nanocarrier for Controlled Doxorubicin Delivery,” porous nanosilica particles are modified with PEG shell via disulfide bridges and supramolecular interaction for drug delivery, with benefits of enhanced drug loading capacity and decreased risk of systemic toxicity. Poly(amino acids) are an important kind of biocompatible and biodegradable synthetic polymers and have been studied for biomedical application in many fields . Degradation is important in biomedicine for many reasons. Although these polymers are often mildly hydrophobic, ester bond stability causes them to undergo bulk erosion.21 Because of the relative ease of their synthesis (via ring-opening or condensation polymerization) and commercial availability, poly(a-esters) have been the D,, Since the last decade, the methods of polymer synthesis, processing, and characterization are developing rapidly, which bring both challenges and opportunities to design novel polymeric biomaterials as well as to understand the biological behaviors between biological systems and polymeric materials. By continuing you agree to the use of cookies. Copyright © 2015 Southwest Jiaotong University. Polymer fibers could be obtained from natural and synthetic polymers at a length scale from the nanometer to micrometer range. 2018, Article ID 7158621, 2 pages, 2018. https://doi.org/10.1155/2018/7158621, 1Max Planck Institute for Medical Research, Heidelberg, Germany, 3University of Freiburg, Freiburg, Germany. The use of synthetic poly (amino acids) as polymers for biomedical devices would seem a logical choice, given their wide occurrence in nature. In summary, this special issue connects the synthetic polymers to biomaterials science and engineering. Print Book & E-Book. A Processable Shape Memory Polymer System for Biomedical Applications Adv Healthc Mater. Sign up here as a reviewer to help fast-track new submissions. Polyethylene glycol (PEG) is another one of the most commonly used synthetic polymers for biomaterials. The book opens by presenting important background information on polymer chemistry and physicochemical characterization of polymers. Tumor models produced via these 3D scaffolds have obvious advantages in anticancer drug screening, which can facilitate the observations of cancer biomarker expression, molecular regulation of cancer progression, and drug efficacies across tumors at similar sizes and developmental stages. Not to be confused with bioplastics, usually semi-synthetic polymers produced from renewable biomass sources. Therefore, they are of increasing interest in a wide range of biomedical applications as diverse as tissue engineering, drug delivery, therapeutics, diagnostics, and so on. fabricated 3D porous scaffolds via PLGA and another biodegradable synthetic polymer polycaprolactone (PCL) in the article “Application of Synthetic Polymeric Scaffolds in Breast Cancer 3D Tissue Cultures and Animal Tumor Models.” It has proven that cancer cells grown on 3D polymeric scaffolds exhibit distinct survival, morphology, and proliferation compared to those on 2D polymeric surfaces. antimicrobial coatings for catheters or implants, one has to bear in mind that the mechanism of antimicrobial surface activity and in-solution activity of polymers is different, even for one and the same polymer. Research pertaining to conductive polymers has gained significant traction in recent years, and their applications range from optoelectronics to material science. G. Rijal et al. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. We sincerely hope that the readers enjoy reading the presented original research work in this special issue and get inspired for their future studies. This review gives a brief overview about the introduction and developments of polymers in medicine in general, addressing first stable polymers, then polymers with degradability as a first biological function, followed by various other functional and responsive polymers. Currently, new polymers that can increase the cell proliferation and the tissue regeneration are of a high interest. Resorbable polymers in bone repair and regeneration 5. The main body of the review then is structured according to the medical applications, where key requirements of the applications and the currently used polymer solutions are indicated. A wide range of different polymers is available, and they have further the advantage to be tunable in physical, chemical and biological properties in a wide range to match the requirements of specific applications. This serves as essential scientific support for the subsequent chapters, each of which is devoted to the applications of polymers in a particular medical … Natural polymers, or polymers, derived from living creatures, are of great interest in the biomaterials field. Synthetic poly (lactic-co-glycolic acid) (PLGA) is widely considered as a base material for biomedical applications due to its good biocompatibility and degradability. Biopolymers consist of monomeric units that … Polymers, an international, peer-reviewed Open Access journal. Biopolymers are natural polymers produced by the cells of living organisms. These fibers could be formed into different configurations such as single, core–sheath, hollow, blended, or composite according to human needs. In December 2020, Alfa Chemistry announced the launch of a new sub-website for the supply of functional polymers, including Adsorptive Polymers, Biomedical Polymers, Electrofunctional Polymers, Functional PEGs, Photoactive Polymers, Silicone Polymers and more. The very first reported synthetic polymer for medical use is poly (methyl methacrylate) (PMMA) by a British ophthalmologist, Sir Nicholas Harold, in 1949 for making intraocular lens [2]. When thinking about biomedical applications beyond mere drugs, e.g. Biomedical applications of composite resorbable fibers 6. New York, USA – December 24, 2020 – In December 2020, the US-based chemical supplier, Alfa Chemistry announced the launch of a new sub-website for the supply of functional polymers, including Adsorptive Polymers, Biomedical Polymers, Electrofunctional Polymers, Functional PEGs, Photoactive Polymers, Silicone Polymers and more.With unstopping efforts, the company continues to … Biocompatible polymers are both synthetic (man-made) and natural and aid in the close vicinity of a living system or work in intimacy with living cells. Current trends and biomedical applications of resorbable polymers 4. Degradation of the polymeric implant means surgical intervention may not be required in order to remove the implant at the end of its functional life, eliminating the need for a … For Authors For Reviewers For Editors For Librarians For Publishers For Societies. Based on the study of mechanics, PLGA is further processed by injection molding as craniofacial bioresorbable medical devices in the article “Effect of Injection Molding Melt Temperatures on PLGA Craniofacial Plate Properties during In Vitro Degradation.” The mechanical and physicochemical properties of the PGA plates are evaluated in detail during in vitro degradation. There is subsequently an overview of the most frequently used polymer classes. Owing to the advances of modern synthetic polymer chemistry, varieties of functional polymers have been developed for various applications including optoelectronics, catalysis, biomaterials, medicine, building materials, water treatment, coatings, and many more. Polymers have been emerging to be the cornerstones for therapeutic applications as well as the largest and versatile class of biomaterials. ISBN 9780128163498, 9780128166048 Qiang Wei, Nan-Nan Deng, Junling Guo, Jie Deng, "Synthetic Polymers for Biomedical Applications", International Journal of Biomaterials, vol. We are committed to sharing findings related to COVID-19 as quickly as possible. aliphatic chains can be utilized as degradable polymers for biomedical applications. Multiple biological, synthetic and hybrid polymers are used for multiple medical applications. Hydrogels are three-dimensional hydrophilic polymeric networks that can be made from a wide range of natural and synthetic polymers. It is shown up that biomedical polymers comprise not only bulk materials, but also coatings and pharmaceutical nano-carriers for drugs. 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